The answer is INURE, five letters. It means to make someone used to something unpleasant through long or repeated exposure, which is the heart of habituate. ENURE is an alternative spelling of equal length, so let the crossing at the first square decide between I and E before you commit.
INURE hides an old word for work
INURE is a contraction. In the early 1400s English had the phrase in ure, meaning in practice, built on an obsolete noun ure, which meant work, practice or use. That noun probably came from Old French uevre or oeuvre, work, and ultimately from Latin opera. To put something in ure was to put it into practice, and by the middle 1400s the verb inure meant to accustom, adapt or establish by use.
The same Latin idea of work sits behind manure, which began around 1400 as a verb meaning to cultivate land by manual labor, from Medieval Latin manuoperare, to work with the hands. Only in the 1590s did it turn toward spreading dung on the soil. The shared root is a reminder that inure was never about comfort. It was about practice, the repeated effort that makes a hardship feel ordinary.
Lawyers keep a second sense of the word alive. In legal writing, a right or benefit is said to inure to someone, meaning it takes effect or operates in that person’s favor, as when a right of way inures to the benefit of a neighbor. That sense never drives a Habituate clue, but it explains why the word can look oddly familiar from contracts and deeds.

USE, INURE, SEASON and ACCUSTOM by length
Match your slot length to a row below:
| Letters | Answer | What tips it |
|---|---|---|
| 3 | USE | The older sense behind used to |
| 5 | INURE | The default, especially for hardship |
| 5 | ENURE | Alternative spelling of INURE |
| 6 | SEASON | Hardening through time or experience |
| 8 | ACCUSTOM | The plain, neutral long option |
The five-square tie is the one to watch. INURE and ENURE differ only in the first letter, so the crossing in that square decides it and nothing else can. Because both spellings end in NURE, solving the other four crossings will never break the tie, so it is worth writing that first letter in lightly until its own crossing is done. ENURE is less common, but it is not an error. Dictionaries list it as an alternative form, and it does turn up in grids. If the clue is flipped and reads Accustom, INURE is still the lead answer, and a nine-square slot can even take HABITUATE itself.
Habituation in psychology and biology
In psychology and biology, habituation has a precise meaning. It is a form of non-associative learning in which an organism’s response to a harmless stimulus shrinks after the stimulus is repeated or prolonged. Prairie dogs offer a clear case. They sound alarm calls when mammals, snakes or large birds approach, but they habituate to repeated human footsteps that bring no harm, and they stop spending energy on those warnings.
That scientific sense is gentler than INURE. Inure nearly always implies something unpleasant to be tolerated, such as cold, pain, criticism or danger. Habituate can cover neutral things, like a noise that turns out to mean nothing. The bare clue does not care about that difference, but a clue that stresses hardship leans toward INURE and SEASON rather than ACCUSTOM.
SEASON works on timber and people alike
SEASON is the six-letter answer and the most physical of the group. Timber is seasoned by drying it until it hardens and loses its natural juices, and the same verb describes making a person fit through experience, which is the sense behind a seasoned traveler. Dictionaries also give season as a direct synonym for habituate, with examples like to season oneself to a climate.
USE is the surprise at three squares. English once used it to mean accustom or habituate, and that sense now survives mainly in the participle, as in soldiers who are used to hardship and danger. When the grid gives you only three boxes under this clue, that old sense is what the setter is relying on, and the short word is easy to overlook because it looks too plain to be the answer.
Frequently asked questions
What is the answer to the Habituate crossword clue?
INURE is the standard five-letter answer. It means to make someone used to something hard or unpleasant through repeated exposure. ENURE is a variant spelling of the same length, SEASON fits six squares, ACCUSTOM fits eight, and USE covers three.
Is ENURE a misspelling of INURE?
No. Dictionaries list ENURE as an alternative form of INURE with the same meaning. Because the two differ only in the first letter, the crossing in that square is the only thing that can tell you which spelling the puzzle wants.
Where does the word inure come from?
It is a contraction of the Middle English phrase in ure, meaning in practice. Ure was a noun for work or use, probably from Old French uevre, work, which goes back to Latin opera. So the verb first meant to accustom or establish by use.