The answer is ERGO, four letters. It is the Latin word for therefore, taken into English unchanged and still used to introduce a conclusion. THUS fits the same four squares, HENCE needs five and SO covers two, so with a Therefore clue the length of the slot narrows the field before logic or tone comes into it.
A Latin conclusion word that never needed translating
ERGO came into English around 1400 directly from Latin, where it meant therefore or in consequence of. It arrived with a narrow professional job. In logic it introduced the conclusion of a syllogism, the line that follows once the premises have been set out above it. Those syllogism roots explain the faint air of the lecture hall ERGO still carries, even when someone drops it into a casual argument about whose turn it is to cook.
Two Latin phrases keep it in everyday circulation. Cogito, ergo sum, usually rendered I think, therefore I am, is the starting point of the philosophy of Descartes. Post hoc, ergo propter hoc means after this, therefore because of this, and it names the informal fallacy of assuming that one event caused another simply because it came first. Blank out the middle word of either Latin saying and the clue can only want ERGO.

From SO to AS A RESULT, sorted by blanks
Count the blanks, then read down the list:
| Letters | Answer | When it fits |
|---|---|---|
| 2 | SO | Tight corners and chatty clues |
| 4 | ERGO | The default, especially with a Latin or logic hint |
| 4 | THUS | Plain English with a formal edge |
| 4 | THEN | If this, then that reasoning |
| 5 | HENCE | Proofs, reports and formal prose |
| 5 | ANDSO | The phrase and so, written as one string |
| 6 | THENCE | Literary wording |
| 6 | THUSLY | Jokey or informal clues |
| 9 | ASARESULT | The phrase as a result, run together |
The four-letter tie is easier to break than it looks. Line ERGO up against THUS and THEN and no square matches: E sits over T, R over H, G over U or E, O over S or N. Any single crossing therefore separates it from both. THUS and THEN are the stubborn pair, because both open with TH. You need the third or fourth square to split them, and an S in the last box means THUS.
HENCE began as a word about places
HENCE is older than its logical job. It descends from Old English heonan, and for its first stretch in English it meant away from here. By the late 1300s it could also mean from this moment onward, a sense that survives in phrases like a year hence. The meaning a Therefore clue relies on, from this fact or circumstance, is not recorded until the 1580s. Even the CE ending is a spelling choice, adopted in the middle 1400s to show that the final sound is a hissed S, the same device used in once, twice and since.
THENCE does both jobs as well, from there and therefore, and dictionaries label its reasoning sense literary. THUSLY has a stranger story. Its earliest known use is 1865, in a piece of dialect humor, and it may have begun as a joke about people who did not realize THUS was already an adverb. Some readers still regard it as incorrect, so treat it as a last resort at six squares.
An S at the end is not a plural here
Therefore is an adverb, so it carries no tense and no number, and every candidate is an adverb or an adverbial phrase. That switches off two checks solvers lean on. With most clues, a final S hints at a plural and an ED hints at the past tense. For Therefore, a closing S just spells out THUS, and no tense ending is waiting to be found.
What replaces those checks is tone. A clue that mentions Latin, logic or a philosopher points to ERGO. Wording lifted from a geometry proof or a formal report suits HENCE. A breezy clue in a small corner suits SO, and a nine-square slot that opens with A is worth testing against AS A RESULT before anything else. Mathematicians even keep a symbol for the word, three dots in an upright triangle, and turning that triangle upside down gives the sign read as because.
Frequently asked questions
What is the answer to the Therefore crossword clue?
ERGO is the usual answer at four letters. It is the Latin word for therefore and appears in Cogito, ergo sum. If ERGO does not fit, try THUS or THEN at four letters, HENCE or AND SO at five, and SO in a two-square slot.
How do I choose between ERGO, THUS and THEN?
Get one crossing letter. ERGO shares no letter in the same position with THUS or THEN, so any checked square rules it in or out. THUS and THEN both begin with TH, so you need the third or fourth square to separate those two.
Does the word ergonomics come from ergo?
No. Ergonomics was coined in 1950 from the Greek ergon, meaning work, joined to the ending of economics. Ergo is a Latin adverb meaning therefore. The shared letters are a coincidence, so a clue about office chairs or workplace design is not hinting at ERGO.